Current Issue : July- September Volume : 2012 Issue Number : 3 Articles : 1 Articles
Gemifloxacin is a synthetic fluoroquinolone broad spectrum anti microbial agent used in the treatment of bacterial infections and it is presently available in the market only as tablet dosage form. It is preferred in the treatment of adults with community acquired pneumonia and acute bacterial exacerbations of chronic bronchitis caused by susceptible organism. The present study was undertaken with an intention to develop a stable and effective parenteral formulation, containing the drug Gemifloxacin. Gemifloxacin is a light sensitive and water soluble drug but unstable at higher temperature in water. So the effects of various co solvents in the solubility of gemifloxacin have been evaluated. Gemifloxacin was tried with co solvents such as Propylene glycol, Tween 80 and Glycerin. The drug was made into injection formulation for administered as a SVP. Various batches of Gemifloxacin injection formulation were prepared in order to assess the influence of heat, light, atmospheric oxygen and antioxidant on the stability of the drug and the formulations were also subjected to accelerated stability testing in order to predict approximate shelf-life of the product. Out of all trials, formulation containing 45% of propylene glycol was found to be more stable with shelf life of 3.23 years and passed all tests satisfactorily....
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